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Crohn's Disease Essay - Words | Bartleby
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gingpoteamskar.tk The investigators behind the new study propose that, subject to further research, Crohn's disease should perhaps join that list. A recent paper in the journal Nutrients gives details of the case together with the researchers' findings and conclusions. Hana Kahleova, director of clinical research at the Physicians Committee for Responsible Medicine in Washington, DC, "offers hope for hundreds of thousands of people [experiencing] the painful symptoms associated with Crohn's disease. Crohn's disease is one of two main forms of IBD. IBD is a condition of persistent inflammation that results in damage to the digestive, or gastrointestinal, tract.
The other form of IBD is ulcerative colitis.
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Although it most often affects the small intestine, Crohn's can occur in any part of the digestive tract between the mouth and the anus. Ulcerative colitis mainly affects the colon, or large intestine, and the rectum. The symptoms of Crohn's disease tend to include abdominal pain, diarrhea , bleeding from the rectum, weight loss, and fatigue.
They can vary from person to person and can come and go. The study authors note that around half of people with Crohn's disease require surgery within 10 years of receiving a diagnosis. Only a small minority achieve "prolonged clinical remission. Scientists are undecided about the exact causes of IBD. However, they suspect that the conditions arises from a complex interplay of several factors that include genetics, diet, lifestyle, environment, immune system changes, and gut bacteria imbalances.
One study paper states that IBD is a global disease that is on the rise in every continent.
It already affects more than 1 million people in the United States and 2. This was quite unexpected. Past work has focussed on discovering genes underlying disease initiation, and our work suggests these may no longer be relevant by the time a patient sees the doctor. One of the genetic variants discovered by the team was in a gene called FOXO3. Another of the variants was close to the gene IGFBP1, which is known to play a role in the immune system. This genetic region, too, has previously been linked to rheumatoid arthritis, in a study looking at the presence of a particular antibody in patients — presence of this antibody is associated with more severe disease.
No Cure for Crohn's Disease
The third genetic variant was in the MHC region, which is responsible for determining how our immune cells respond to invading organisms. The study has been welcomed by Crohn's and Colitis UK, who helped fund the study. By dividing the patients into groups categorised by disease severity, the researchers were able ask new questions — and gain new insights — from the old data. Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. The text in this work is licensed under a Creative Commons Attribution 4.
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